Search results for " memory B cells"

showing 2 items of 2 documents

Memory B Cell Subpopulations in the Aged

2006

The literature on immunosenescence has focused mainly on T cell impairment. With the aim of gaining insight into B cell immunosenescence, the authors investigated the serum IgD levels in 24 young and 21 old people and analyzed their relationship with the number of CD19 CD27 memory cells. Serum IgD were quantified by the use of radial immunodiffusion and the lymphocyte population CD19 CD27 was identified by a FACScan flow cytometer. Serum IgD levels were significantly lower (p 0.0001) in old subjects, and the percentage of CD19 CD27 lymphocytes were significantly increased (p 0.01) in old subjects. Finally, a significant negative correlation was found (p 0.01) between serum concentrations of…

AdultMalemedicine.medical_specialtyAgingLymphocyteT cellPopulationAntigens CD19B-Lymphocyte Subsetschemical and pharmacologic phenomenaimmunosenescence memory B cells IgD CD27Immunoglobulin DCD19immune system diseaseshemic and lymphatic diseasesInternal medicinemedicineHumanseducationMemory B cellB cellAgedAged 80 and overSettore MED/04 - Patologia Generaleeducation.field_of_studybiologyhemic and immune systemsImmunosenescenceImmunoglobulin DTumor Necrosis Factor Receptor Superfamily Member 7Endocrinologymedicine.anatomical_structureImmunologybiology.proteinFemaleGeriatrics and GerontologyImmunologic Memory

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CD27 distinguishes two phases in bone marrow infiltration of splenic marginal zone lymphoma.

2004

Aims: To investigate CD27 expression in splenic marginal zone lymphoma (SMZL), an indolent low-grade B-cell lymphoma with constant involvement of the bone marrow, especially with an intrasinusoidal pattern. It is not clear if the neoplastic clone is composed of virgin or somatically mutated B cells. CD27 is reported to be a hallmark of memory B cells. Methods and results: We evaluated 64 bone marrow biopsy specimens (BMBs) from 36 patients with SMZL for the expression of CD27. For comparison, splenectomy specimens of patients with traumatic splenic rupture or with SMZL were used. All BMBs showed lymphomatous infiltration. When located in the marrow sinusoids, neoplastic cells were CD27– i…

AdultMalePathologymedicine.medical_specialtyHistologybone marrowLymphomaBiopsyNaive B cellsplenic marginal zone lymphomaSplenic NeoplasmSpleenPathology and Forensic MedicineBiopsyintrasinusoidal infiltrationmedicineHumansSplenic marginal zone lymphomaCD27naive and memory B cellsAgedAged 80 and overmedicine.diagnostic_testbusiness.industrySplenic NeoplasmsGeneral MedicineMiddle Agedmedicine.diseaseBone Marrow NeoplasmImmunohistochemistryTumor Necrosis Factor Receptor Superfamily Member 7bone marrow; CD27; intrasinusoidal infiltration; naive and memory B cells; splenic marginal zone lymphomamedicine.anatomical_structureBone marrow neoplasmFemaleBone marrowbusinessBone Marrow NeoplasmsInfiltration (medical)

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